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The management of isolated positive syphilis enzyme immunoassay results in HIV-negative patients attending a sexual health clinic.

Thorley, Nicola and Adebayo, Michael and Smit, Erasmus and Radcliffe, Keith (2016) The management of isolated positive syphilis enzyme immunoassay results in HIV-negative patients attending a sexual health clinic. International journal of STD & AIDS, 27 (9). pp. 798-800. ISSN 1758-1052.

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Official URL: http://journals.sagepub.com/doi/abs/10.1177/095646...

Abstract

An unconfirmed positive treponemal enzyme immunoassay (enzyme immunoassay positive, Treponema pallidum particle agglutination negative and rapid plasma reagin negative) presents a clinical challenge to distinguish early syphilis infection from false-positive results. These cases are referred for syphilis line assay (INNO-LIA) and recalled for repeat syphilis serology. We performed a retrospective audit to establish the proportion of HIV-negative cases with unconfirmed positive enzyme immunoassay results, the proportion of these cases that received an INNO-LIA test and repeat syphilis serology testing and reviewed the clinical outcomes; 0.35% (80/22687) cases had an unconfirmed positive treponemal enzyme immunoassay result. Repeat syphilis serology was performed in 80% (64/80) cases, but no additional cases of syphilis were identified. Eighty-eight per cent (70/80) received an INNO-LIA test; 14% (5/37) unconfirmed enzyme immunoassay-positive cases with no prior history of syphilis were confirmed on INNO-LIA assay, supporting a diagnosis of latent syphilis. As a confirmatory treponemal test, the INNO-LIA assay may be more useful than repeat syphilis serological testing.

Item Type: Article
Subjects: HQ Sex. Relationships. Marriage. The family
QW Microbiology. Immunology
WC Communicabable diseases
Divisions: Clinical Support > Infectious Diseases
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Depositing User: Mrs Yolande Brookes
Date Deposited: 20 Jan 2017 16:01
Last Modified: 20 Jan 2017 16:01
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/1122

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