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Expression and activity of Toll-like receptors 1-9 in the human term placenta and changes associated with labor at term.

Patni, Shalini and Wynen, Louise P and Seager, Anna L and Morgan, Gareth and White, John O and Thornton, Catherine A (2009) Expression and activity of Toll-like receptors 1-9 in the human term placenta and changes associated with labor at term. Biology of reproduction, 80 (2). pp. 243-8. ISSN 0006-3363.

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Official URL: http://www.biolreprod.org/content/80/2/243.long

Abstract

Inflammatory processes are involved in the initiation and maintenance of labor, suggesting that Toll-like receptor (TLR) activity within gestation-associated tissues, such as the placenta, might contribute to the process of parturition. Expression of transcripts for TLR1-TLR10 was examined in term (>37 wk of gestation) human placentas collected in the absence of labor (elective caesarean sections; ECS; n = 11) and after the completion of labor (normal vaginal delivery; NVD; n = 12). Placental explants were cultured in the presence of agonists for TLR2, TLR3, TLR4, TLR5, TLR7, TLR8, and TLR9, and cytokine production after 24 h was examined. All placentas expressed transcripts for TLR1-TLR10. Reactivity to all agonists except CpG oligonucleotides was observed, indicating that, other than TLR9, all of the receptors studied yielded functional responses. Placental explants prepared from NVD placentas (n = 17) produced significantly more TNFA in response to lipopolysaccharide (TLR4 agonist) and resiquimod (TLR7/8 agonist) than explants from ECS placentas (n = 17). In contrast, gene expression analysis revealed that only transcripts for TLR2 and TLR5 were significantly elevated in association with labor. The human term placenta expresses a variety of functional TLRs, indicating that this family of receptors has an important role in parturition via as yet undetermined cell types and signaling pathways.

Item Type: Article
Subjects: WQ Obstetrics. Midwifery
Divisions: Womens and Childrens > Obstetrics
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Depositing User: Users 6 not found.
Date Deposited: 02 Jul 2014 10:27
Last Modified: 02 Jul 2014 10:27
URI: http://www.repository.heartofengland.nhs.uk/id/eprint/105

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